Christina Applegate reveals struggles with multiple sclerosis I look like Humpty Dumpty in a heartfelt and candid discussion on the latest episode of her messy podcast Christina Applegate opened up about her ongoing battle with multiple sclerosis Ms and the significant changes it has brought to her life the 52-year-old actress best known for her roles in Married with Children and dead to me shared her feelings of physical vulnerability and emot turmoil as she navigates Her diagnosis which she revealed in August 2021 during her conversation with co-host jamlin Sigler Applegate likened her current physical state to that of Humpty Dumpty saying I have no muscles in my legs I look like Humpty Dumpty like my little tiny weird legs and then my big menopausal belly this striking imagery underscores the challenges she faces with her body image as she contends with the debilitating effects of Ms which severely impacts the central nervous system Applegate candidly explained that Her diagnosis has forced her to limit her physical activities drastically everyone I know who wants to do something with me they know it's not going to be a hike in the Hills that's not going to happen because I'm so not conditioned right now she said acknowledging that even simple tasks can lead to significant strain if I go up a hill my heart starts beating really fast and I think I'm going to have a heart attack because the muscle isn't there this reality has led Applegate to issue a disclaimer to her friends informing them that she may have to cancel plans at the last minute due to her health if you want to go to lunch just know and you have to know this and you can't be mad at me that if right before you come to pick me up if I say can't do it you can't be mad she explained if I'm puking or can't walk you think I'm going to go to a restaurant or go do anything no I'm not going to do that despite the severe limitations that Ms has imposed on her life Applegate is still grappling with the emotional aspect of Her diagnosis she shared her ongoing struggle to accept that she is a different version of herself now you either feel stty or you feel less stty when you have Miz there's never like oh my God I'm back to who I was before all this happened she lamented I will never be the girl I was in 2020 I will never be that person again and that's what I have to accept her Reflections reveal the profound impact that Ms has had not only on her physical abilities but also on her mental health Applegate has been open about her experiences with depression stating that she is currently struggling with a deep sense of hopelessness in a previous episode of her podcast she shared I'm in a depression right now which I don't think I've felt that for years I'm trapped in like this Darkness right now that I haven't felt me like I don't even know how long probably 20s something years Applegates battle with Ms has led to numerous challenges in her daily routine she has previously shared harrowing experiences such as falling in the shower while trying to shave and needing to wear diapers due to her loss of control these candid admissions highlight the harsh realities of living with an incurable autoimmune disease emphasizing the need for greater understanding and compassion from the public in June she revealed in a stark statement that she does not enjoy living anymore citing the emotional and physical toll of her condition I have 30 lesions on my brain and lost circulation in my legs during an MS relapse she said underscoring the severity of her health issues and their impact on her quality of life Christina Applegate has made limited public appearances since Her diagnosis often using a cane for support she surprised fans with a cameo at the Emmy Awards in January 2023 a moment that was both inspiring and poignant showcasing her resilience in the face of adversity despite her struggles Applegate continues to find ways to connect with her audience and raise awareness about Ms advocating for greater understanding of the disease as she navigates this challenging chapter of her life Applegate's openness about her experiences serves as a source of inspiration for others facing similar Battles by sharing her journey she not only Fosters a sense of community but also highlights the importance of empathy and support for those living with chronic illnesses in her ongoing fight against multiple sclerosis Christina Applegate exemplifies strength and vulnerability reminding us all of the human spirit's capacity to endure even in the face of overwhelming challenges