[Music] hello and welcome to Medical dialogues I'm Dr GMA Soni let's look at today's top medical news old chemotherapy drug effective against pancreatic cancer a recent study published in the journal proceedings from National Academy of Sciences indicates that a common chemotherapy supplement called fenic acid weakens the Cancer's defenses in pancreatic ductal adenocarcinoma the battle against caner resembles an arms race with immuno therapy emerging as one of the most powerful tool available to clinicians immune checkpoint therapy has become a standard treatment for various cancers nevertheless it often proves ineffective for majority of patients with pancreatic ductal adenocarcinoma previously it was believed that pancreatic ductal adenocarcinoma did not provoke an immune response however recent researches have proved that immune cells do indeed attack the tumors the problem is that these cells have difficulty penetrating the aggressive tumors allowing pancreatic ductal adenocarcinoma to evade destruction promising new strategy to slow cancer progression the findings were published in nature chemistry reveals that protein targets of cancer protein when disrupted with particular chemical compounds or small molecules may help to stop cancer cell growth potentially leading to creation of more effective and targeted cancer treatments in this study scientists outlined activity based protein profiling a technique that allows for the global capture of protein activity the research team applied this technique alongside another approach to identify both the proteins and specific sites that interacted with a set of stereo probes chemical compounds designed to selectively and permanently bind to proteins these stereo probes help investigate protein functions and uncover potential duct targets the research team's stopes were electrophilic designed to permanently bind to proteins specifically targeting the amino acid suine elevated dementia risk linked to acute kidney injury a recent study published in the journal neurology finds that acute kidney injury is linked to a higher risk of developing dementia acute kidney injury which involves a rapid decline in kidney function is fairly common among older adults and is linked to higher rates of illness and death previously Studies have suggested that a potential link between acute kidney injury and bra brain injury the study explored the link between acute kidney injury and various forms of Dementia by analyzing data from 3 lakh individuals aged 65 years and older approximately L 25% of participants experienced at least one episode of acute kidney injury during an average follow-up period of 12 years and 16% were diagnosed with dementia revolutionary needle-free intranasal covid-19 vaccine a recent paper published in the nature Communications reveals the efficacy of delivering a covid-19 vaccine via the nasal passages these vaccines are live attenuated intranasal vaccine called CD 7n1 which are delivered through intranasal passages that induces robust mucosal and systemic neutralizing antibody and t- cell subset responses that when tested in mice which was triggered by a single immunization the virus that causes covid-19 known as sarc 2 has led to more than 700 million infections and 7 million deaths around the world so far it still possess a serious threat to people who are vulnerable that's all for today stay tuned to Medical dialogues for latest updates never miss a medical update from Medical dialogues like subscribe and press the Bell icon